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Robert Hoffman, PhD

Professor of Surgery



Contact Information

(858) 654-2555

Research Overview

Our research program centers on cancer with the ultimate goal of developing a general cure.

Research Topics

  • Angiogenesis
  • Cancer
  • Cell Biology
  • Development
  • Drug Delivery
  • Genetics
  • Genomics
  • Regeneration/Stem Cells
  • Translational Research

Current Project Titles

  • Tumor killing bacteria
  • Pluripotent hair follicle stem cells for nerve regeneration
  • Imaging the cellular and subcellular steps of metastasis in vivo
  • Methionine-depletion cancer therapy
  • Imaging cell cycle progression in vivo for chemotherapy drug targeting
  • Developing visual cellular targets for cancer therapy
  • Circulating tumor cells as targets for chemotherapy
  • Development of fluorescence-guided surgery
  • Orthotopic mouse models of human patient tumors:
    • Schmitt, C.A., Fridman, J.S., Yang, M., Baranov, E., Hoffman, R.M. and Lowe, S.W. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1, 289-298, 2002. (view cover)
    • Soda, Y., Marumoto, T., Friedmann-Morvinski, D., Soda, M., Liu, F., Michiue, H., Pastorino, S., Yang, M., Hoffman, R.M., Kesari, S., Verma, I.M. Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc. Natl. Acad. Sci. USA 108, 4274-4280, 2011. (view cover)
  • The role of exosomes and micro-RNA in cancer metastasis
  • Identification and characterization of cancer stem cells
  • Genetic exchange between cancer cells and between cancer cells and stroma
  • Role of macrophages in tumor growth
  • Color-coded imaging of the tumor micro-environment and its role in tumor progression and metastasis